LIAM KOZMA
2023 Metabolic Engineering Python SciPy / DEAP Project Lead

L-Asparaginase Strain Engineering

Senior capstone executed over 2022 and 2023 as a year-long simulated venture. Founded and led a team of biochemical engineers and held primary stakeholder responsibility.

Partnered with Dr. Yajun Yan's lab to engineer E. coli strains for elevated L-asparaginase expression, an enzyme used to treat acute lymphoblastic leukemia and to suppress acrylamide formation in food. Built a Python model on SciPy and DEAP to optimize fed-batch reactor mass balance.

Scoped intellectual property, biosafety, and regulatory compliance into the design. Placed top three at UGA's Quick Pitch Competition.

L-asparaginase capstone title slide
Project title slide