LIAM KOZMA
2021 Bioprocess Design Simulation Downstream

Monoclonal Antibody Bioprocess

Bioprocess design and simulation for a monoclonal antibody facility operating under the simulated firm Anti Biologics in Athens, GA. Sized the process for 100 g/day output from murine myeloma and C5-immunized B cells through culture, filtration, purification, and lyophilization.

Modeled full process economics: $20/g production cost against an $800/g sale price, yielding $28.47M in annual profit, benchmarked against Soliris.

Monoclonal antibody bioprocess diagram
Process design and simulation